[Model Based Meta Analysis] Placebo response changes depending on the neuropathic pain syndrome: results of a systematic review and meta-analysis

2018-06-14

OBJECTIVE:
To compare placebo responses in neuropathic pain syndromes.
CONCLUSIONS:
Placebo response is influenced by the pain syndrome evaluated. These differences should be considered when evaluating novel compounds for the treatment of neuropathic pain conditions.

[Model Based Meta Analysis] Placebo response changes depending on the neuropathic pain syndrome: results of a systematic review and meta-analysis

2012-04-13

Objective: To compare placebo responses in neuropathic pain syndromes.

Design: Systematic literature review and meta-analysis.

Setting and patients: Randomized placebo-controlled trials assessing pain intensity or pain relief in any neuropathic pain syndrome published since 1995 with ≥5days follow-up.

Interventions: Placebo response.

Outcome measures: Pain intensity and responder rates (proportion reporting ≥50% pain relief). Meta-regression models were built.

Results: Ninety-four studies (N=5,317) were included in the pain intensity analysis; 47 studies (N=3,087) were included ......